Find Research Outputs

2018

Capecitabine versus S-1 as adjuvant chemotherapy for patients with stage III colorectal cancer (JCOG0910): an open-label, non-inferiority, randomised, phase 3, multicentre trial

Hamaguchi, T. , Shimada, Y. , Mizusawa, J. , Kinugasa, Y. , Kanemitsu, Y. , Ohue, M. , Fujii, S. , Takiguchi, N. , Yatsuoka, T. , Takii, Y. , Ojima, H. , Masuko, H. , Kubo, Y. , Mishima, H. , Yamaguchi, T. , Bando, H. , Sato, T. , Kato, T. , Nakamura, K. , Fukuda, H. & 1 others Moriya, Y. 2018 Jan 1 In : The Lancet Gastroenterology and Hepatology. 3, 1, p. 47-56 10 p.

Research output: Research - peer-reviewArticle

Adjuvant Chemotherapy
Multicenter Studies
Colorectal Neoplasms
Capecitabine
Disease-Free Survival

Extracellular vesicle-encapsulated microRNA-761 enhances pazopanib resistance in synovial sarcoma

Shiozawa, K., Shuting, J., Yoshioka, Y., Ochiya, T. & Kondo, T. 2018 Jan 1 In : Biochemical and Biophysical Research Communications. 495, 1, p. 1322-1327 6 p.

Research output: Research - peer-reviewArticle

Synovial Sarcoma
MicroRNAs
Extracellular Vesicles
pazopanib
Proteins

In situ dual-crosslinked nanoparticles for tumor targeting gene delivery

Zhang, Y., Liu, L., Lin, L., Chen, J., Tian, H., Chen, X. & Maruyama, A. 2018 Jan 1 In : Acta Biomaterialia. 65, p. 349-362 14 p.

Research output: Research - peer-reviewArticle

Tumors
Genes
Nanoparticles
DNA
Gene Targeting
1 Citations

Pyruvic acid prevents Cu2+/Zn2+-induced neurotoxicity by suppressing mitochondrial injury

Tanaka, K. I., Shimoda, M. & Kawahara, M. 2018 Jan 1 In : Biochemical and Biophysical Research Communications. 495, 1, p. 1335-1341 7 p.

Research output: Research - peer-reviewArticle

Pyruvic Acid
Zinc
Wounds and Injuries
Cell Death
Cell death

Recent trends in analytical methods for the determination of amino acids in biological samples

Song, Y., Xu, C., Kuroki, H., Liao, Y. & Tsunoda, M. 2018 Jan 5 In : Journal of Pharmaceutical and Biomedical Analysis. 147, p. 35-49 15 p.

Research output: Research - peer-reviewReview article

Amino Acids
Fluids
Biological Phenomena
Ketone Bodies
Fluorescence Spectrometry
C-Reactive Protein
Monolayers
Phospholipids
Proteins
proteins
1 Citations

Thioredoxin-albumin fusion protein prevents copper enhanced zinc-induced neurotoxicity via its antioxidative activity

Tanaka, K. I., Shimoda, M., Chuang, V. T. G., Nishida, K., Kawahara, M., Ishida, T., Otagiri, M., Maruyama, T. & Ishima, Y. 2018 Jan 15 In : International Journal of Pharmaceutics. 535, 1-2, p. 140-147 8 p.

Research output: Research - peer-reviewArticle

Thioredoxins
Zinc
Copper
Albumins
Proteins
Lectins
Boronic Acids
Ribose
Biocompatible Materials
Biomolecules
2017

64Cu-ATSM internal radiotherapy to treat tumors with bevacizumab-induced vascular decrease and hypoxia in human colon carcinoma xenografts

Yoshii, Y., Yoshimoto, M., Matsumoto, H., Furukawa, T., Zhang, M. R., Inubushi, M., Tsuji, A. B., Fujibayashi, Y., Higashi, T. & Saga, T. 2017 Jan 1 In : Oncotarget. 8, 51, p. 88815-88826 12 p.

Research output: Research - peer-reviewArticle

Blood Vessels
Colon
Radiotherapy
Carcinoma
Neoplasms
1 Citations

67Cu-Radiolabeling of a multimeric RGD peptide for α v β 3 integrin-targeted radionuclide therapy: Stability, therapeutic efficacy, and safety studies in mice

Jin, Z. H., Furukawa, T., Ohya, T., Degardin, M., Sugyo, A., Tsuji, A. B., Fujibayashi, Y., Zhang, M. R., Higashi, T., Boturyn, D., Dumy, P. & Saga, T. 2017 In : Nuclear Medicine Communications. 38, 4, p. 347-355 9 p.

Research output: Research - peer-reviewArticle

Integrin alphaVbeta3
Radioisotopes
Safety
Therapeutics
cyclam

A clinical predictive score for postoperative myasthenic crisis

Kanai, T. , Uzawa, A. , Sato, Y. , Suzuki, S. , Kawaguchi, N. , Himuro, K. , Oda, F. , Ozawa, Y. , Nakahara, J. , Suzuki, N. , Takahashi, Y. K. , Ishibashi, S. , Yokota, T. , Ogawa, T. , Yokoyama, K. , Hattori, N. , Izaki, S. , Oji, S. , Nomura, K. , Kaneko, J. & 3 others Nishiyama, K., Yoshino, I. & Kuwabara, S. 2017 Nov 1 In : Annals of Neurology. 82, 5, p. 841-849 9 p.

Research output: Research - peer-reviewArticle

Muscle Weakness
Myasthenia Gravis
Thymectomy
Logistic Models
Therapeutics

A combination of circulating miRNAs for the early detection of ovarian cancer

Yokoi, A., Yoshioka, Y., Hirakawa, A., Yamamoto, Y., Ishikawa, M., Ikeda, S. I., Kato, T., Niimi, K., Kajiyama, H., Kikkawa, F. & Ochiya, T. 2017 Jan 1 In : Oncotarget. 8, 52, p. 89811-89823 13 p.

Research output: Research - peer-reviewArticle

MicroRNAs
Early Detection of Cancer
Ovarian Neoplasms
Neoplasms
Exosomes
2 Citations
Polymers
poly(2-oxazoline)
polymers
polymerization
platforms

Ameliorative effect of chlorpromazine hydrochloride on visceral hypersensitivity in rats: possible involvement of 5-HT2A receptor

Asano, T., Tanaka, K. I., Tada, A., Shimamura, H., Tanaka, R., Maruoka, H., Mizushima, T. & Takenaga, M. 2017 Jan 1 In : British Journal of Pharmacology. 174, 19, p. 3370-3381 12 p.

Research output: Research - peer-reviewArticle

Chlorpromazine
Serotonin
Hypersensitivity
Butyrates
Irritable Bowel Syndrome
2 Citations

Amigo2-upregulation in tumour cells facilitates their attachment to liver endothelial cells resulting in liver metastases

Kanda, Y., Osaki, M., Onuma, K., Sonoda, A., Kobayashi, M., Hamada, J., Nicolson, G. L., Ochiya, T. & Okada, F. 2017 Mar 8 In : Scientific Reports. 7, 43567

Research output: Research - peer-reviewArticle

HMGB1 Protein
Open Reading Frames
Up-Regulation
Endothelial Cells
Neoplasm Metastasis
1 Citations

Aminophylline suppresses stress-induced visceral hypersensitivity and defecation in irritable bowel syndrome

Asano, T., Tanaka, K. I., Tada, A., Shimamura, H., Tanaka, R., Maruoka, H., Takenaga, M. & Mizushima, T. 2017 Jan 5 In : Scientific Reports. 7, 40214

Research output: Research - peer-reviewArticle

Aminophylline
Defecation
Irritable Bowel Syndrome
Hypersensitivity
Purinergic P1 Receptors
1 Citations

A Phase II/III randomized controlled trial comparing perioperative versus postoperative chemotherapy with mFOLFOX6 for lower rectal cancer with suspected lateral pelvic node metastasis: Japan Clinical Oncology Group Study JCOG1310 (PRECIOUS study)

Ohue, M., Iwasa, S., Kanemitsu, Y., Hamaguchi, T., Shiozawa, M., Ito, M., Yasui, M., Katayama, H., Mizusawa, J., Shimada, Y., Colorectal Cancer Study Group & Japan Clinical Oncology Group 2017 In : Japanese Journal of Clinical Oncology. 47, 1, p. 84-87 4 p.

Research output: Research - peer-reviewArticle

Medical Oncology
Rectal Neoplasms
Japan
Randomized Controlled Trials
Neoplasm Metastasis

A phase II study of combination therapy with oral S-1 and cisplatin in elderly patients with advanced gastric cancer

Sasaki, Y., Iwasa, S., Okazaki, S., Goto, M., Kojima, Y., Naganuma, A., Nagashima, K., Nagai, Y., Hirano, H., Honma, Y., Takashima, A., Kato, K. & Hamaguchi, T. 2017 Aug 1 (Accepted/In press) In : Gastric Cancer. p. 1-7 7 p.

Research output: Research - peer-reviewArticle

Cisplatin
Stomach Neoplasms
Therapeutics
Treatment Failure
Disease-Free Survival
4 Citations

A polymeric micelle magnetic resonance imaging (MRI) contrast agent reveals blood–brain barrier (BBB) permeability for macromolecules in cerebral ischemia-reperfusion injury

Shiraishi, K., Wang, Z., Kokuryo, D., Aoki, I. & Yokoyama, M. 2017 May 10 In : Journal of Controlled Release. 253, p. 165-171 7 p.

Research output: Research - peer-reviewArticle

Micelles
Tissue Plasminogen Activator
Reperfusion Injury
Brain Ischemia
Blood-Brain Barrier
1 Citations

A Prospective, Multicenter Phase II Study of the Efficacy and Feasibility of 15-minute Panitumumab Infusion Plus Irinotecan for Oxaliplatin- and Irinotecan-refractory, KRAS Wild-type Metastatic Colorectal Cancer (Short Infusion of Panitumumab Trial)

Akiyoshi, K., Hamaguchi, T., Yoshimura, K., Takahashi, N., Honma, Y., Iwasa, S., Takashima, A., Kato, K., Yamada, Y., Onodera, H., Takeshita, S., Yasui, H., Sakai, G., Akatsuka, S., Ogawa, K., Horita, Y., Nagai, Y. & Shimada, Y. 2017 Jan 1 (Accepted/In press) In : Clinical Colorectal Cancer.

Research output: Research - peer-reviewArticle

irinotecan
oxaliplatin
Feasibility Studies
Colorectal Neoplasms
panitumumab

A tissue microRNA signature that predicts the prognosis of breast cancer in young women

Hironaka-Mitsuhashi, A., Matsuzaki, J., Takahashi, R. U., Yoshida, M., Nezu, Y., Yamamoto, Y., Shiino, S., Kinoshita, T., Ushijima, T., Hiraoka, N., Shimizu, C., Tamura, K. & Ochiya, T. 2017 Nov 1 In : PLoS ONE. 12, 11, e0187638

Research output: Research - peer-reviewArticle

microRNA
breast neoplasms
prognosis
tissues
MicroRNAs

Biological and clinical insights offered by chemically induced liver progenitors (CLiPs)

Katsuda, T. & Ochiya, T. 2017 Aug 1 In : Stem Cell Investigation. 4, 8, 68

Research output: Research - peer-reviewLetter

Liver
3 Citations

Block copolymer-boron cluster conjugate for effective boron neutron capture therapy of solid tumors

Mi, P., Yanagie, H., Dewi, N., Yen, H. C., Liu, X., Suzuki, M., Sakurai, Y., Ono, K., Takahashi, H., Cabral, H., Kataoka, K. & Nishiyama, N. 2017 May 28 In : Journal of Controlled Release. 254, p. 1-9 9 p.

Research output: Research - peer-reviewArticle

Boron Neutron Capture Therapy
Boron
Neoplasms
Intracellular Space
Ethylene Glycol
4 Citations

Block Copolymer Micellization as a Protection Strategy for DNA Origami

Agarwal, N. P., Matthies, M., Gür, F. N., Osada, K. & Schmidt, T. L. 2017 (Accepted/In press) In : Angewandte Chemie - International Edition.

Research output: Research - peer-reviewArticle

Micellization
Block copolymers
DNA
Medical nanotechnology
Molecular biology
1 Citations
Lysophosphatidylcholines
C-Reactive Protein
Monolayers
Phospholipids
Calcium
9 Citations

Cancer progression by reprogrammed BCAA metabolism in myeloid leukaemia

Hattori, A., Tsunoda, M., Konuma, T., Kobayashi, M., Nagy, T., Glushka, J., Tayyari, F., McSkimming, D., Kannan, N., Tojo, A., Edison, A. S. & Ito, T. 2017 May 25 In : Nature. 545, 7655, p. 500-504 5 p.

Research output: Research - peer-reviewArticle

Branched Chain Amino Acids
Myeloid Leukemia
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Neoplasms
Blast Crisis

Cancer stromal targeting therapy

Matsumura, Y. 2017 In : Yakugaku Zasshi. 137, 5, p. 529-534 6 p.

Research output: Research - peer-reviewReview article

Neoplasms
Therapeutics
Fibrin
Monoclonal Antibodies
Antibodies
Gold
Agglomeration
Copolymers
Nanoparticles
DNA

Cationic copolymer augments membrane permeabilizing activity of an amphiphilic peptide

Sakamoto, W., Ochiai, T., Shimada, N. & Maruyama, A. 2017 Feb 17 (Accepted/In press) In : Journal of Biomaterials Science, Polymer Edition. p. 1-12 12 p.

Research output: Research - peer-reviewArticle

Allylamine
Dextrans
Grafts
Copolymers
Membranes

Chaperone-Polymer-Assisted, Photodriven DNA Strand Displacement

Cheng, B., Kashida, H., Shimada, N., Maruyama, A. & Asanuma, H. 2017 Aug 17 In : ChemBioChem. 18, 16, p. 1568-1572 5 p.

Research output: Research - peer-reviewArticle

Dextrans
Grafts
Lysine
Polymers
Irradiation
3 Citations

Chronic treatment of non-small-cell lung cancer cells with gefitinib leads to an epigenetic loss of epithelial properties associated with reductions in microRNA-155 and -200c

Narita, M., Shimura, E., Nagasawa, A., Aiuchi, T., Suda, Y., Hamada, Y., Ikegami, D., Iwasawa, C., Arakawa, K., Igarashi, K., Kuzumaki, N., Yoshioka, Y., Ochiya, T., Takeshima, H., Ushijima, T. & Narita, M. 2017 Feb 1 In : PLoS ONE. 12, 2, e0172115

Research output: Research - peer-reviewArticle

lung neoplasms
microRNA
epigenetics
cells
neoplasm cells
1 Citations

Circulating exosomal microRNA-203 is associated with metastasis possibly via inducing tumor-associated macrophages in colorectal cancer

Takano, Y., Masuda, T., Iinuma, H., Yamaguchi, R., Sato, K., Tobo, T., Hirata, H., Kuroda, Y., Nambara, S., Hayashi, N., Iguchi, T., Ito, S., Eguchi, H., Ochiya, T., Yanaga, K., Miyano, S. & Mimori, K. 2017 Jan 1 In : Oncotarget. 8, 45, p. 78598-78613 16 p.

Research output: Research - peer-reviewArticle

MicroRNAs
Colorectal Neoplasms
Macrophages
Neoplasm Metastasis
Neoplasms
1 Citations

Circulating MicroRNA-92b-3p as a Novel Biomarker for Monitoring of Synovial Sarcoma

Uotani, K., Fujiwara, T., Yoshida, A., Iwata, S., Morita, T., Kiyono, M., Yokoo, S., Kunisada, T., Takeda, K., Hasei, J., Numoto, K., Nezu, Y., Yonemoto, T., Ishii, T., Kawai, A., Ochiya, T. & Ozaki, T. 2017 Dec 1 In : Scientific Reports. 7, 1, 14634

Research output: Research - peer-reviewArticle

Synovial Sarcoma
MicroRNAs
Biomarkers
Serum
Neoplasms
9 Citations

Circulating microRNAs and extracellular vesicles as potential cancer biomarkers: a systematic review

Matsuzaki, J. & Ochiya, T. 2017 Feb 27 (Accepted/In press) In : International Journal of Clinical Oncology. p. 1-8 8 p.

Research output: Research - peer-reviewArticle

Long Noncoding RNA
Tumor Biomarkers
MicroRNAs
Extracellular Vesicles
Untranslated RNA

Clinical application of DDS in cancer chemotherapy

Hamaguchi, T. 2017 In : Drug Delivery System. 32, 2, p. 93 1 p.

Research output: Research - peer-reviewEditorial

Drug Therapy
Neoplasms

Clinical outcomes of resectable esophageal cancer with supraclavicular lymph node metastases treated with curative intent

Honma, Y., Hokamura, N., Nagashima, K., Sudo, K., Shoji, H., Iwasa, S., Takashima, A., Kato, K., Hamaguchi, T., Boku, N., Umezawa, R., Ito, Y., Itami, J., Koyanagi, K., Igaki, H. & Tachimori, Y. 2017 Jul 1 In : Anticancer Research. 37, 7, p. 3741-3749 9 p.

Research output: Research - peer-reviewArticle

Esophageal Neoplasms
Lymph Nodes
Neoplasm Metastasis
Survival
Chemoradiotherapy
7 Citations

Clinical significance of circulating miR-25-3p as a novel diagnostic and prognostic biomarker in osteosarcoma

Fujiwara, T., Uotani, K., Yoshida, A., Morita, T., Nezu, Y., Kobayashi, E., Yoshida, A., Uehara, T., Omori, T., Sugiu, K., Komatsubara, T., Takeda, K., Kunisada, T., Kawamura, M., Kawai, A., Ochiya, T. & Ozaki, T. 2017 In : Oncotarget. 8, 20, p. 33375-33392 18 p.

Research output: Research - peer-reviewArticle

Osteosarcoma
Biomarkers
Serum
MicroRNAs
Culture Media

Clinicopathological features and pathological evaluation of preoperative treatment of patients with resectable esophageal carcinosarcoma

Katsuya, Y., Honma, Y., Taniguchi, H., Kato, K., Okita, N., Takashima, A., Iwasa, S., Hamaguchi, T., Boku, N., Umezawa, R., Inaba, K., Ito, Y., Itami, J., Koyanagi, K., Igaki, H. & Tachimori, Y. 2017 May 29 (Accepted/In press) In : Esophagus. p. 1-7 7 p.

Research output: Research - peer-reviewArticle

Carcinosarcoma
Therapeutics
Chemoradiotherapy
Drug Therapy
Survival

Combined treatment of pancreatic cancer xenograft with 90Y-ITGA6B4-mediated radioimmunotherapy and PI3K/mTOR inhibitor

Aung, W., Tsuji, A. B., Sudo, H., Sugyo, A., Ukai, Y., Kouda, K., Kurosawa, Y., Furukawa, T., Saga, T. & Higashi, T. 2017 Nov 14 In : World Journal of Gastroenterology. 23, 42, p. 7551-7562 12 p.

Research output: Research - peer-reviewArticle

Radioimmunotherapy
Pancreatic Neoplasms
Phosphatidylinositol 3-Kinases
Therapeutics
dactolisib

Comparison of response to chemotherapy between ovarian and extraovarian metastasis of gastric cancer

Ishimoto, U., Nakamura, S., Sasaki, Y., Takahashi, N., Iwasa, S., Honma, Y., Okita, N., Takashima, A., Kato, K., Hamaguchi, T. & Boku, N. 2017 Mar 1 In : Japanese Journal of Cancer and Chemotherapy. 44, 3, p. 233-237 5 p.

Research output: Research - peer-reviewArticle

Stomach Neoplasms
Neoplasm Metastasis
Drug Therapy
Survival
Ovary

Controlled Fab installation onto polymeric micelle nanoparticles for tuned bioactivity

Chen, S., Florinas, S., Teitgen, A., Xu, Z. Q., Gao, C., Wu, H., Kataoka, K., Cabral, H. & Christie, R. J. 2017 Dec 31 In : Science and Technology of Advanced Materials. 18, 1, p. 666-680 15 p.

Research output: Research - peer-reviewArticle

Micelles
Bioactivity
Nanoparticles
Bearings (structural)
Cytotoxicity
9 Citations

Conversion of Terminally Committed Hepatocytes to Culturable Bipotent Progenitor Cells with Regenerative Capacity

Katsuda, T., Kawamata, M., Hagiwara, K., Takahashi, R. U., Yamamoto, Y., Camargo, F. D. & Ochiya, T. 2017 Jan 5 In : Cell Stem Cell. 20, 1, p. 41-55 15 p.

Research output: Research - peer-reviewArticle

Hepatocytes
Stem Cells
Liver
In Vitro Techniques
Liver Regeneration
4 Citations

Copper enhances zinc-induced neurotoxicity and the endoplasmic reticulum stress response in a neuronal model of vascular dementia

Tanaka, K. I. & Kawahara, M. 2017 Feb 9 In : Frontiers in Neuroscience. 11, FEB, 58

Research output: Research - peer-reviewArticle

Vascular Dementia
Endoplasmic Reticulum Stress
Zinc
Copper
Ions
2 Citations
Nanomedicine
Neoplastic Stem Cells
Cisplatin
Neoplasms
Carcinoma, squamous cell of head and neck
5 Citations

cRGD peptide-installed epirubicin-loaded polymeric micelles for effective targeted therapy against brain tumors

Quader, S., Liu, X., Chen, Y., Mi, P., Chida, T., Ishii, T., Miura, Y., Nishiyama, N., Cabral, H. & Kataoka, K. 2017 Jul 28 In : Journal of Controlled Release. 258, p. 56-66 11 p.

Research output: Research - peer-reviewArticle

Epirubicin
Micelles
Glioblastoma
Brain Neoplasms
Therapeutics
5 Citations

Cross-Linking versus Non-Cross-Linking Aggregation of Gold Nanoparticles Induced by DNA Hybridization: A Comparison of the Rapidity of Solution Color Change

Wang, G., Akiyama, Y., Shiraishi, S., Kanayama, N., Takarada, T. & Maeda, M. 2017 Jan 18 In : Bioconjugate chemistry. 28, 1, p. 270-277 8 p.

Research output: Research - peer-reviewArticle

Gold
Agglomeration
Nanoparticles
Color
DNA
4 Citations

Cross talk between neurometals and amyloidogenic proteins at the synapse and the pathogenesis of neurodegenerative diseases

Kawahara, M., Kato-Negishi, M. & Tanaka, K. 2017 Jun 1 In : Metallomics. 9, 6, p. 619-633 15 p.

Research output: Research - peer-reviewReview article

Amyloidogenic Proteins
Neurodegenerative Diseases
Synapses
Metals
Neurodegenerative diseases

Dark field microscopic analysis of discrete Au nanostructures: Understanding the correlation of scattering with stoichiometry

Wang, G., Bu, T., Zako, T., Watanabe-Tamaki, R., Tanaka, T. & Maeda, M. 2017 Sep 16 In : Chemical Physics Letters. 684, p. 310-315 6 p.

Research output: Research - peer-reviewArticle

stoichiometry
scattering
Stoichiometry
Nanostructures
Scattering

Demonstration of thermo-sensitive tetra-gel with implication for facile and versatile platform for a new class of smart gels

Matsumoto, A., Sato, S., Sakamaki, T., Sanjo, M., Tabata, M., Goda, T., Asoh, T. A., Kikuchi, A. & Miyahara, Y. 2017 Apr 20 (Accepted/In press) In : Journal of Biomaterials Science, Polymer Edition. p. 1-10 10 p.

Research output: Research - peer-reviewArticle

Demonstrations
Gels
poly-N-isopropylacrylamide
Polymers
Bearings (structural)

Depressive disorder may be associated with raphe nuclei lesions in patients with brainstem infarction

Numasawa, Y., Hattori, T., Ishiai, S., Kobayashi, Z., Kamata, T., Kotera, M., Ishibashi, S., Sanjo, N., Mizusawa, H. & Yokota, T. 2017 Apr 15 In : Journal of Affective Disorders. 213, p. 191-198 8 p.

Research output: Research - peer-reviewArticle

Brain Stem Infarctions
Raphe Nuclei
Depressive Disorder
Apathy
Depression